It is the only cardiac valvular disease that is predominantly rheumatic in origin and acounts for about 50 percent of all rheumatic valve disease.

MSは、ほとんどがリウマチ性に生じる唯一の心臓弁膜症であり、全リウマチ性弁膜症の約50%を占める。

in origin  http://eow.alc.co.jp/in+origin/UTF-8/?ref=sa

predominantly  http://eow.alc.co.jp/predominantly/UTF-8/